Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model
J. Clin. Invest. Christophe Dubois, et al. 117:953 doi:10.1172/JCI30537 [Go to this article.]

Figure 5
Calcium mobilization per platelet in WT mice, vWF^–/– mice, FcRγ^–/– mice, and WT mice treated with lepirudin. In order to calculate calcium mobilization per platelet, the ratios of the signals corresponding to platelet accumulation and calcium mobilization (as assessed by the median integrated fluorescence intensity of each) were compared. (A) Platelet accumulation. (B) Calcium mobilization per platelet, presented as a ratio. FcRγ^–/–, FcRγ^–/– mice lacking GPVI; WT + lepirudin, WT mice treated with lepirudin.