Inherited human cPLA_2α deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction
J. Clin. Invest. David H. Adler, et al. 118:2121 doi:10.1172/JCI30473 [Go to this article.]

Figure 3
Platelet-derived eicosanoid biosynthesis. Serum TxB₂ was measured by GC/MS, and serum 12-HETE was measured by LC/MS. Normal values for serum eicosanoids were obtained from healthy male volunteers (n = 49 for TxB₂; n = 42 for 12-HETE). The lower limits of the reference ranges are represented by the 0.025 quantiles for normal volunteers (brackets represent 0.025 quantiles ± SEM). Mean values are represented by horizontal bars. Individual measurements are plotted for patient (closed circles) and heterozygous family members (open circles).