Hypothalamic resistin induces hepatic insulin resistance
J. Clin. Invest. Evan D. Muse, et al. 117:1670 doi:10.1172/JCI30440 [Go to this article.]

Figure 3
Real-time RT-PCR and Western immunoblot analysis of hepatic inflammation and insulin signaling. (A) icv resistin administration (black bars) increased hepatic gene expression of proinflammatory mediators SOCS-3, IL-6, and TNF-α compared with vehicle-treated animals (white bars) but had no change on IKK-β, FAS, ACC1, SCD1, and PPARγ. (B and C) Significant decreases in total Stat3 protein and p-GSK3β were detected in the livers following central resistin administration (black bars), with a reciprocal but converse elevation in SOCS-3 when compared with controls (white bars). The levels of p–IκB-α remained unchanged (C). *P < 0.05 compared with vehicle.