TRAIL limits excessive host immune responses in bacterial meningitis
J. Clin. Invest. Olaf Hoffmann, et al. 117:2004 doi:10.1172/JCI30356 [Go to this article.]

Figure 6
Effects of treatment with rTRAIL in meningitis induced by live pneumococci. (A) At 24 hours after infection, bacterial load in the CSF in untreated and rTRAIL-treated wild-type mice did not differ. (B) CSF leukocyte concentration was significantly lower in rTRAIL-treated mice than in controls at 24 hours after infection with live pneumococci. **P < 0.01, Student’s t test. (C) During the experimental period of 24 hours, mortality was higher in untreated versus rTRAIL-treated mice with meningitis. **P < 0.01, log rank test. (D) Apoptosis in the dentate gyrus at 24 hours after meningitis induction was reduced by treatment with 1 μg rTRAIL. **P < 0.01, Student’s t test.