TRAIL limits excessive host immune responses in bacterial meningitis
J. Clin. Invest. Olaf Hoffmann, et al. 117:2004 doi:10.1172/JCI30356 [Go to this article.]

Figure 5
Myeloid cells are the source of TRAIL in experimental meningitis. (A) In BM chimeric mice, the degree of chimerism was assessed by FACS analysis of peripheral blood leukocytes. Histogram plot demonstrates strong enhanced GFP expression in leukocyte populations from a chimera compared with that in leukocytes from a nontransplanted mouse. (B) The degree of CSF inflammation at 24 hours after meningitis induction in BM chimeric mice is determined by the genotype of the BM donor. Note that the levels of chimerism were comparable among all 4 groups of chimeras. CSF pleocytosis correlated negatively with TRAIL deficiency in hematopoietic cells. (C) Real-time PCR revealed presence of TRAIL mRNA in wild-type and TRAIL^–/– mice transplanted with wild-type BM (C57/C57 and TRAIL^–/–/C57, respectively) but absence of TRAIL mRNA expression in TRAIL^–/– mice transplanted with TRAIL^–/– BM (TRAIL^–/–/TRAIL^–/–). bps, base pairs.