Hypoxia-inducible factor–2 (HIF-2) regulates hepatic erythropoietin in vivo
J. Clin. Invest. Erinn B. Rankin, et al. 117:1068 doi:10.1172/JCI30117 [Go to this article.]

Figure 5
Inhibition of Hif prolyl hydroxylation results in an Hif-2–dependent induction of hepatic Epo. Relative Epo mRNA levels in the liver of albumin-Cre mutant mice treated with either with normal saline or 10 mg of DMOG as determined by real-time PCR. Bars represent the mean Epo mRNA transcript level of 3 mice for the WT and albumin–Hif-1α mutants (Hif-1α^–/–) and 5 mice for the albumin-Hif-2α (Hif-2α^–/–) mutants. Error bars represent SEM. *P < 0.05 compared with albumin–Hif-2α mutant mice as determined by the Wilcoxon rank sum test.