Deficiency of Src homology 2 domain–containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth
J. Clin. Invest. Sonia Séverin, et al. 117:944 doi:10.1172/JCI29967 [Go to this article.]

Figure 5
Impaired bleeding time and thrombus formation in SHIP1-deficient mice. (A) The tail bleeding time of WT (n = 12) and SHIP1-deficient (n = 5) mice was measured as described in Methods. (B) Thrombus formation over time following laser-induced injury of mesenteric artery wall of WT and SHIP1-deficient mice was followed by intravital microscopy (objective, ×40; scale bar: 20 μm). The mean thrombus surface was analyzed at 0.3-second intervals, and the shading over the curve represents the SEM at each time point in 6 WT mice (n = 22 vessels) and 6 SHIP1-deficient mice (n = 16 vessels). Time 0 corresponds to the time of injury.