Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy
J. Clin. Invest. Matthew R. Ritter, et al. 116:3266 doi:10.1172/JCI29683 [Go to this article.]

Figure 4
HIF-1α expression is required for myeloid progenitors to mediate repair in the OIR model. (A and B) Representative GS lectin–stained retina whole mounts from eyes treated with CD44^hi cells from myeloid-specific HIF-1α knockout mice (A) or wild-type mice (B). (C and D) Quantified areas of vascular obliteration (yellow) and neovascular tufts (red) in retinas from A and B. (E) Compiled data showing significant loss of repair activity in the eyes treated with CD44^hi cells from HIF-1α knockouts. ^†P ≤ 0.0003, ^‡P = 0.024. Values represent mean ± SEM (n = 15). Statistics were generated using paired eyes. Magnification, ×4.