Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo
J. Clin. Invest. Raogo Ouedraogo, et al. 117:1718 doi:10.1172/JCI29623 [
Go to this article.]
Figure 5Adiponectin deficiency increases E-selectin and VCAM-1 expression levels in the vascular endothelium of the mouse microcirculation. Representative sections of ileal venules (Vs) staining positive for E-selectin are shown in the top 3 photomicrographs. E-selectin staining in all experimental groups of mice was detected by avidin/biotin immunoperoxidase technique seen as brown reaction product (arrows). Original magnification, ×500. Bottom graphs show quantification of the percentage of venules staining positive for E-selectin (left) and VCAM-1 (right). Values are mean ± SEM. Numbers at base of bars indicate the number of mice studied in each group. Five tissue sections were studied in each mouse, and 50 venules were analyzed per section.
