Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo
J. Clin. Invest. Raogo Ouedraogo, et al. 117:1718 doi:10.1172/JCI29623 [Go to this article.]

Figure 3
Pharmacologically active doses of gAd reverse TNF-α–induced leukocyte-endothelium interactions in WT mice. As shown in A and B, 1 μg/kg TNF-α given 2 hours before the experiment increases leukocyte rolling flux and leukocyte adhesion, respectively, in the microcirculation of WT mice. Two 25 μg doses of gAd given 24 hours and 2.5 hours before intravital microscopy significantly attenuates TNF-α–induced leukocyte rolling and adhesion, confirming the potent antiinflammatory action of pharmacologic doses of gAd also in mice expressing physiologic adiponectin levels. Data are expressed as the mean ± SEM. Numbers at the base of the bars indicate the number of mice studied in each group.