The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage
J. Clin. Invest. Wensheng Lin, et al. 117:448 doi:10.1172/JCI29571 [Go to this article.]

Figure 4
Real-time PCR analysis for the expression pattern of cytokines in the spinal cord at the peak of disease. (A) CNS delivery of IFN-γ did not significantly affect the expression of iNOs. (B) CNS delivery of IFN-γ did not significantly affect the expression of TNF-α. (C) CNS delivery of IFN-γ decreased the expression of IL-2 in the spinal cords of mice on a Perk^+/+ background, but did not change IL-2 expression in mice on a Perk^+/– background. (D) CNS delivery of IFN-γ decreased the expression of IL-12 in the spinal cords of mice on a Perk^+/+ background, but did not change IL-12 expression in mice on a Perk^+/– background. (E) CNS delivery of IFN-γ decreased the expression of IL-23 in the spinal cords of mice on a Perk^+/+ background, but did not change IL-23 expression in mice on a Perk^+/– background. (F) CNS delivery of IFN-γ did not significantly affect the expression of IL-5. (G) CNS delivery of IFN-γ did not significantly affect the expression of IL-10. (H) CNS delivery of IFN-γ did not significantly affect the expression of IL-17. Error bars represent SD. n = 3. *P < 0.05 versus IFN-γ^CNS–;Perk^+/+.