Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy
J. Clin. Invest. Amy M. Avila, et al. 117:659 doi:10.1172/JCI29562 [Go to this article.]

Figure 2
TSA treatment increases histone acetylation and gene expression in nontransgenic mice. (A) Representative Western blot showing acetylated H3 (Ac H3) histones compared with H1 histone levels in the brains of nontransgenic mice 2 hours after treatment with vehicle (Veh) or with 2, 5, or 10 mg/kg TSA. Each lane represents an individual animal. (B) Quantification of acetylated H3 and H4 histones in the brains and livers of nontransgenic mice treated with vehicle or with 2, 5, or 10 mg/kg TSA. (C) Mouse Smn and follistatin (Foll) mRNA levels after treatment with vehicle or with 2, 5, or 10 mg/kg TSA. Values represent mean ± SEM of 3 mice per group. *P < 0.01; ^#P < 0.05.