Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy
J. Clin. Invest. Amy M. Avila, et al. 117:659 doi:10.1172/JCI29562 [Go to this article.]

Figure 1
TSA activates the SMN2 gene in vitro. (A) The SMA fibroblast cell line 2906 was treated with 0–50 nM TSA, and SMN+7 and SMNΔ7 mRNA was measured after 4 hours. Values represent mean ± SEM of 5 separate experiments. (B) The SMA fibroblast cell line 3813 was treated with 50 nM TSA, and SMN+7 and SMNΔ7 mRNA levels were determined over a period of 0–72 hours. Values represent mean ± SEM of 2 experiments for the 2-, 4-, 17-, and 24-hour time points and 1 experiment for the 0.5-, 1-, 5-, 48-, and 72-hour time points.