Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation
J. Clin. Invest. Alexander Zarbock, et al. 116:3211 doi:10.1172/JCI29499 [Go to this article.]

Figure 5
Blocking TXA₂ prevents acid-induced ALI. (A) ALI induced increased plasma TXB₂ levels at 2 hours. Platelet depletion partially reduced TXB₂ levels (n = 4–5 mice per group). (B–D) Blocking of TPs (n = 4–5 mice per group) significantly improved gas exchange (B), reduced PMN accumulation in the intravascular, interstitial (data not shown), and alveolar compartments (C), and prevented increased vascular permeability (D). ASS showed similar effects regarding PMN recruitment and permeability (C–D), but the effect on gas exchange was not as pronounced as in TP blockade (B). ^#P < 0.05.