Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
J. Clin. Invest. Decheng Ren, et al. 117:397 doi:10.1172/JCI29417 [Go to this article.]

Figure 3
Neuron-specific restoration of SH2B1 corrects energy imbalance in SH2B1^KO mice. (A) Food intake in WT, SH2B1^Tg, SH2B1^KO, and SH2B1^TgKO-437 mice at age 14–15 weeks. (B) O₂ consumption and CO₂ production in WT, SH2B1^Tg, SH2B1^KO, and SH2B1^TgKO-437 mice at age 16–17 weeks. *P < 0.05.