Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis
J. Clin. Invest. Anne L. Astier, et al. 116:3252 doi:10.1172/JCI29251 [
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Figure 5Aberrant CD46 cytoplasmic isoform expression in T cells from MS patients. (
A) Relative expression of each isoform in freshly isolated T cells from healthy controls and either treated or untreated patients with MS. CD46 isoform expression was analyzed in T cells isolated from healthy control or MS patients. The ΔCt value is plotted [ΔCt = Ct (Cyt) – Ct (S9)]. (
B) Relative increase in expression of CD46 cytoplasmic isoforms after CD46 stimulation. Cyt1 and Cyt2 expression in activated T cells was determined after stimulation by CD3/CD46 after 3 or 24 hours. Their expression relative to expression at t0 is represented and expressed in AU.
