ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury
J. Clin. Invest. Kensuke Noma, et al. 118:1632 doi:10.1172/JCI29226 [
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Figure 2ROCK expression in leukocytes and carotids of
Rock1+/– and
Rock2+/– mice.
(
A) Expression of ROCK isoforms in leukocytes from WT,
Rock1+/–, and
Rock2+/– mice with and without carotid ligation. Representative western blot (upper panel). Quantification of ROCK1 expression (middle panel). Mean ± SEM;
n = 3. Quantification of ROCK2 expression (lower panel). Mean ± SEM;
n = 3. (
B) Expression of ROCK isoforms in unligated and ligated carotid arteries from WT,
Rock1+/–, and
Rock2+/– mice. Representative western blot (upper panel). Quantification of ROCK1 expression (middle panel). Mean ± SEM;
n = 4. Quantification of ROCK2 expression (lower panel). Mean ± SEM;
n = 4. *
P < 0.05 versus unligated WT mice;
†P < 0.01 versus unligated
Rock2+/– mice;
ΧP < 0.01 versus ligated WT and
Rock2+/– mice; **
P < 0.01 versus unligated WT and
Rock1+/– mice;
‡P < 0.01 versus ligated WT mice;
#P < 0.05 versus ligated
Rock1+/– mice;
##P < 0.01 versus unligated WT and
Rock2+/– mice; ***
P < 0.01 versus WT and
Rock1+/– mice.
