Insulin resistance and pancreatic β cell failure
J. Clin. Invest. Masato Kasuga, et al. 116:1756 doi:10.1172/JCI29189 [
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Figure 1Development of type 2 diabetes. Insulin resistance associated with obesity is induced by adipokines, FFAs, and chronic inflammation in adipose tissue. Pancreatic β cells compensate for insulin resistance by hypersecretion of insulin. However, at some point, β cell compensation is followed by β cell failure, and diabetes ensues.
