SPDEF regulates goblet cell hyperplasia in the airway epithelium
J. Clin. Invest. Kwon-Sik Park, et al. 117:978 doi:10.1172/JCI29176 [Go to this article.]

Figure 7
Expression of SPDEF caused goblet cell hyperplasia in the conducting airways. CCSP-rtTA/TRE2-Spdef mice were maintained with (B, D, and F) or without (A, C, and E) doxycycline from E0 to postnatal day 14. Lung sections were stained with Alcian blue (A and B) or by immunohistochemistry for MUC5A/C (C and D) and CCSP (E and F). Increased Alcian blue and MUC5A/C staining was readily detected in the conducting airways of mice in the presence (B and D), but not in the absence (A and C), of doxycycline. Expression of SPDEF caused decreased CCSP staining (F) compared with controls without doxycycline (E). Scale bars: 100 μm.