SPDEF regulates goblet cell hyperplasia in the airway epithelium
J. Clin. Invest. Kwon-Sik Park, et al. 117:978 doi:10.1172/JCI29176 [
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Figure 5Comparison of SPDEF and ERM on target gene transcription. Reporter assays were performed using plasmids expressing SPDEF and ERM, an ETS family transcription factor also expressed in the lung. The plasmids were cotransfected with the
firefly luciferase reporter plasmids under control of
Sftpa (
A),
Foxj1 (
B),
Scgb1a1 (
C), and
Sox17 (
D) gene promoters. While SPDEF activated the
Sftpa,
Foxj1,
Scgb1a1, and
Sox17 promoters, ERM was less active. Each assay was repeated in at least 3 experiments with similar results. Values are mean ± SD (
n = 3).
P values shown were obtained by ANOVA.
