Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients
J. Clin. Invest. Tetsushi Sadakata, et al. 117:931 doi:10.1172/JCI29031 [Go to this article.]

Figure 7
Increased cell death of Cadps2^–/– Purkinje cells. (A and B) Cell density of calbindin-positive (A) and MAP2ab-positive (B) neurons in primary dissociated cultures (8 DIV) of WT (white bars) and Cadps2^–/– (black bars) cerebella. Cerebellar cultures were grown in the absence or presence of the BDNF (10 ng/ml). Heat-inactivated BDNF (HI-BDNF; 10 ng/ml; 100°C, 15 minutes) was also used. The medium was changed at 4 DIV with readdition of BDNF or HI-BDNF. The error bars indicate SD. **P < 0.01, Student’s t test.