Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients
J. Clin. Invest. Tetsushi Sadakata, et al. 117:931 doi:10.1172/JCI29031 [Go to this article.]

Figure 6
Abnormal immunohistochemical findings in the Cadps2^–/– mouse hippocampus. (A–C) Sagittal sections of the P8 hippocampus immunostained for CADPS2 (green in A) and BDNF (red in B). A merged image is shown in C. Scale bar: 200 μm. (D–F) Higher magnification of the region shown by the square in A. s.p., stratum pyramidale; s.l., stratum lucidum; s.r., stratum radiatum. Scale bar: 10 μm. (G–J) Sagittal sections of WT (G) and Cadps2^–/– (H–J) P17 hippocampus immunostained for parvalbumin. (I and J) Sections were prepared from P17 Cadps2^–/– mice 12 days after an icv injection of either vehicle (I) or BDNF (J). Scale bars: 500 μm. (K) Cell density of parvalbumin-positive neurons in the P17 hippocampus. The error bars indicate SD. **P < 0.01, Student’s t test.