Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients
J. Clin. Invest. Tetsushi Sadakata, et al. 117:931 doi:10.1172/JCI29031 [
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Figure 4Maternal neglect of newborns by
Cadps2–/– mothers.
(
A) Survival of pups born to virgin
Cadps2–/– (closed circles;
n = 19 mothers),
Cadps2+/– (gray circles;
n = 14 mothers), and WT (open circles;
n = 15 mothers) females mated with WT males. Shown is mean ± SEM. *
P < 0.05; **
P < 0.01, Mann-Whitney
U test. (
B) Number of cages that contained live pups (white bars) versus number of pup extinction cages (black bars) 2 days after birth.