Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients
J. Clin. Invest. Tetsushi Sadakata, et al. 117:931 doi:10.1172/JCI29031 [
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Figure 3An abnormal sleep/wake rhythm of
Cadps2–/– mice.
(
A and
B) Sleep/wake rhythms of locomotor activity under free wheel-running conditions. Representative activity traces of WT (
A) and
Cadps2–/– (
B) mice for 7 days of LD cycle and 14 days of constant darkness (DD) are represented as relative deflections from the horizontal line. Actograms are double-plotted over a 48-hour period. Time is expressed in a 24-hour cycle on the top of
A and
B. (
C) The circadian period (h) calculated by a c
2 periodogram of
Cadps2–/– mice (black bar;
n = 9) and WT littermates (open bar;
n = 8). The error bars indicate the SEM. **
P < 0.01, Student’s
t test.
