Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients
J. Clin. Invest. Tetsushi Sadakata, et al. 117:931 doi:10.1172/JCI29031 [
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Figure 2Autistic-like behavior of
Cadps2–/– mice. (
A) Number of reciprocal interactions of
Cadps2–/– mouse pairs (black bar;
n = 12) and of WT littermate pairs (white bar;
n = 12) for 20 minutes. (
B) Locomotor activity in home cages. After habituation to a fresh cage for 24 hours, the locomotor activity of
Cadps2–/– mice (black bar;
n = 9) and WT littermates (white bar;
n = 9) was measured for 6 days (12-hour LD cycle [LD]). The number of photobeam interruptions per 15 minutes is shown in the
y axis. (
C–
F) Horizontal locomotor activity of
Cadps2–/– mice (filled circles;
n = 15) and of WT littermates (open circles;
n = 17) in an open field is shown in 3 blocks (5 minutes each) in the absence (
C) or presence (
D) of the novel object shown in the upper right of
D. Representative movement traces of WT and
Cadps2–/– are shown in
E and
F, respectively. Error bars indicate the SEM. *
P < 0.05; **
P < 0.01, by Student’s
t test.
