JCI - Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients

Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients

Tetsushi Sadakata, Miwa Washida, Yoshimi Iwayama, Satoshi Shoji, Yumi Sato, Takeshi Ohkura, Ritsuko Katoh-Semba, Mizuho Nakajima, Yukiko Sekine, Mika Tanaka, Kazuhiko Nakamura, Yasuhide Iwata, Kenji J. Tsuchiya, Norio Mori, Sevilla D. Detera-Wadleigh, Hironobu Ichikawa, Shigeyoshi Itohara, Takeo Yoshikawa, Teiichi Furuichi

Published in Volume 117, Issue 4

J Clin Invest. 2007; 117(4):931–943 doi:10.1172/JCI29031

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Figure 2

Autistic-like behavior of Cadps2^–/– mice.

(A) Number of reciprocal interactions of Cadps2^–/– mouse pairs (black bar; n = 12) and of WT littermate pairs (white bar; n = 12) for 20 minutes. (B) Locomotor activity in home cages. After habituation to a fresh cage for 24 hours, the locomotor activity of Cadps2^–/– mice (black bar; n = 9) and WT littermates (white bar; n = 9) was measured for 6 days (12-hour LD cycle [LD]). The number of photobeam interruptions per 15 minutes is shown in the y axis. (C–F) Horizontal locomotor activity of Cadps2^–/– mice (filled circles; n = 15) and of WT littermates (open circles; n = 17) in an open field is shown in 3 blocks (5 minutes each) in the absence (C) or presence (D) of the novel object shown in the upper right of D. Representative movement traces of WT and Cadps2^–/– are shown in E and F, respectively. Error bars indicate the SEM. *P < 0.05; **P < 0.01, by Student’s t test.