Mark A. Herman, Barbara B. Kahn
J Clin Invest.
2006;
116(7):1767–1775
doi:10.1172/JCI29027
This article Copyright © 2006, The American Society for Clinical Investigation
Abstract
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Full text
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R
ecent data underscore the importance of intertissue communication in the maintenance of normal glucose homeostasis. Important signals are conveyed by hormones, cytokines, and fuel substrates and are sensed through a variety of cellular mechanisms. The ability of tissues to sense and adapt to changes in metabolic status and fuel availability is altered in insulin-resistant states including type 2 diabetes. Here we review the roles of glucose and its metabolites as signaling molecules and the diverse physiologic mechanisms for glucose sensing.
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