Primitive hematopoietic cells resist HIV-1 infection via p21^{Waf1/Cip1/Sdi1}
J. Clin. Invest. Jielin Zhang, et al. 117:473 doi:10.1172/JCI28971 [Go to this article.]

Figure 7
Silencing of p21 had no effect on SIVmac-251. (A and B) SIVmac-251 infection of CD34⁺ cells and CD34^– cells. (A) Silencing of p21 expression in CD34⁺ cells did not induce SIVmac-251 replication. SIV antigen p27 was detected from CD34⁺ cells treated with p21 siRNA or control siRNA or cells that were mock treated (SIV infection only). (B) SIVmac-251 replicated in CD34^– cells of the same donor. SIV antigen p27 was detected in CD34^– cells infected with virus (SIV) but not in mock-infected CD34^– cells (M^–). Assays were run in duplicate. Values represent means ± SD (0.01–0.66).