|
|
Jielin Zhang, David T. Scadden, Clyde S. Crumpacker
J Clin Invest. 2007;
117(2):473
doi:10.1172/JCI28971
Abstract |
Full text
| PDF
| Supplemental material
H
ematopoietic stem cells are resistant to HIV-1 infection. Here, we report a novel mechanism by which the cyclin-dependent kinase inhibitor (CKI) p21Waf1/Cip1/Sdi1 (p21), a known regulator of stem cell pool size, restricts HIV-1 infection of primitive hematopoietic cells. Modifying p21 expression altered HIV-1 infection prior to changes in cell cycling and was selective for p21 since silencing the related CKIs, p27Kip1 and p18INK4C, had no effect on HIV-1. We show that p21 blocked viral infection by complexing with HIV-1 integrase and aborting chromosomal integration. A closely related lentivirus with a distinct integrase, SIVmac-251, and the other cell-intrinsic inhibitors of HIV-1, Trim5α, PML, Murr1, and IFN-α, were unaffected by p21. Therefore, p21 is an endogenous cellular component in stem cells that provides a unique molecular barrier to HIV-1 infection and may explain how these cells remain an uninfected “sanctuary” in HIV disease.
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal.
Not all publishers participate in CrossRef, so this information is not comprehensive.
Additionally, data may not reflect the most current citations to this article,
and the data may differ from citation information available from other sources
(for example, Google Scholar, Web of Science, and Scopus).
About CrossRef
| Title and authors |
Publication |
Year |
. |
Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers
A. Saez-Cirion, C. Hamimi, A. Bergamaschi, A. David, P. Versmisse, A. Melard, F. Boufassa, F. Barre-Sinoussi, O. Lambotte, C. Rouzioux |
- |
2011 |
.
|
Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon
Thomas Pertel, Christian Reinhard, Jeremy Luban |
- |
2011 |
.
|
Effects of HIV-1 gp120 and Protease Inhibitors on Apoptotic Susceptibility of CD34+ Hematopoietic Progenitor Cells
Owen J MacEneaney, Elizabeth Connick, Christopher A DeSouza |
- |
2011 |
.
|
Hematopoietic stem and progenitor cells in HIV/AIDS and immune reconstitution
Jielin Zhang, Clyde S Crumpacker |
- |
2010 |
.
|
HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs
Christoph C Carter, Adewunmi Onafuwa-Nuga, Lucy A McNamara, James Riddell, Dale Bixby, Michael R Savona, Kathleen L Collins |
- |
2010 |
.
|
Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes
Lara Manganaro, Marina Lusic, Maria Ines Gutierrez, Anna Cereseto, Giannino Del Sal, Mauro Giacca |
- |
2010 |
.
|
Hiding place for HIV revealed
Janet Fang |
- |
2010 |
.
|
The challenge of obtaining therapeutic levels of genetically modified hematopoietic stem cells in β-thalassemia patients
Derek A. Persons |
- |
2010 |
.
|
RKP, a RING finger E3 ligase induced by BSCTV C4 protein, affects geminivirus infection by regulation of the plant cell cycle
Jianbin Lai, Hao Chen, Kunling Teng, Qingzhen Zhao, Zhonghui Zhang, Yin Li, Liming Liang, Ran Xia, Yaorong Wu, Huishan Guo, Qi Xie |
- |
2009 |
.
|
RNA interference-mediated knockdown of p21WAF1 enhances anti-tumor cell activity of oncolytic adenoviruses
M Shiina, M D Lacher, C Christian, W M Korn |
- |
2009 |
.
|
The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection
J. Haedicke, C. Brown, M. H. Naghavi |
- |
2009 |
.
|
Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration
A. Levin, Z. Hayouka, R. Brack-Werner, D. J. Volsky, A. Friedler, A. Loyter |
- |
2009 |
.
|
p21WAF1 gene promoter is epigenetically silenced by CTIP2 and SUV39H1
T Cherrier, S Suzanne, L Redel, M Calao, C Marban, B Samah, R Mukerjee, C Schwartz, G Gras, B E Sawaya, S L Zeichner, D Aunis, C Van Lint, O Rohr |
- |
2009 |
.
|
Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs
Mayte Coiras, María Rosa López-Huertas, Mayte Pérez-Olmeda, José Alcamí |
- |
2009 |
.
|
Human T-Cell Lymphotropic Virus Type 1 Infection of CD34+Hematopoietic Progenitor Cells Induces Cell Cycle Arrest by Modulation of p21cip1/waf1and Survivin
Prabal Banerjee, Michelle Sieburg, Elizabeth Samuelson, Gerold Feuer |
- |
2008 |
.
|
Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?
Frank Kirchhoff, Guido Silvestri |
- |
2008 |
.
|
Lentiviral Vector Gene Transfer Is Limited by the Proteasome at Postentry Steps in Various Types of Stem Cells
Francesca Romana Santoni de Sio, Angela Gritti, Paolo Cascio, Margherita Neri, Maurilio Sampaolesi, Cesare Galli, Jeremy Luban, Luigi Naldini |
- |
2008 |
.
|
Gene therapy approaches for stem cell protection
J S Greenberger |
- |
2007 |
.
|
Infection of hematopoietic progenitor cells by HIV-1 subtype C, and its association with anemia in southern Africa
A. D. Redd, A. Avalos, M. Essex |
- |
2007 |
.
|
An intrinsic host defense against HIV-1 integration?
Paul D. Bieniasz |
- |
2007 |
.
|
|
|
|