Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function
J. Clin. Invest. Marco Idzko, et al. 117:464 doi:10.1172/JCI28949 [Go to this article.]

Figure 4
Administration of iloprost prevents sensitization induced by DCs. On day 0, mice received an i.t. injection of OVA in the presence or absence of iloprost. From days –1 to 2, mice were injected i.p. with anti–Gr-1 Abs to deplete pDCs or isotype control Abs. Ten days later, mice were exposed to 3 OVA aerosols. (A) BAL fluid was analyzed by flow cytometry. (B) Hematoxylin and eosin staining of lung sections. (C) MLN cells restimulated in vitro for 4 days with OVA, and cytokines were measured in the supernatant. Data are mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001.