Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8⁺ T cells
J. Clin. Invest. Giovanna Gallina, et al. 116:2777 doi:10.1172/JCI28828 [Go to this article.]

Figure 2
CD11b⁺ splenocytes from tumor-bearing mice produce both IFN-γ and IL-13. CD11b⁺ cells isolated from the spleens of normal BALB/c and different tumor-bearing mice (WT BALB/c, IFN-γ^–/–, CD1^–/–, and RAG^–/–γ_c^–/– KO mice) were analyzed by flow cytometry for intracellular presence of IL-13 (top panels) and IFN-γ (bottom panels). Open histograms indicate staining with IL-13 or IFN-γ antibody; filled histograms indicate staining with isotype-matched antibody controls. Data are representative of at least 3 determinations in separate experiments. MFI, mean fluorescence intensity (a log scale of 10⁰–10⁴ was used).