Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor
J. Clin. Invest. Sara H. Windahl, et al. 116:2500 doi:10.1172/JCI28809 [
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Figure 8Estren-α reduces both bone resorption and bone formation in ORX male mice. Histomorphometric analysis was performed on tibiae from the mice described in Figure 7. Both estren-α and DHT reduced the bone formation parameters osteoblast surface (OBS/BS) (
A) and bone formation rate (
B) and the bone resorption parameters osteoclast number (
C) and urinary Dpyr cross-links (
D) in ORX male mice to levels at or below the levels seen in sham-operated animals. In contrast, PSK3471 had little effect on the ORX-induced increases in bone formation and bone resorption. *
P < 0.05 and **
P < 0.01 versus ORX mice.
