Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor
J. Clin. Invest. Sara H. Windahl, et al. 116:2500 doi:10.1172/JCI28809 [Go to this article.]

Figure 7
Estren-α prevents bone loss in ORX WT male mice. DHT, PSK3471, and estren-α are all fully protective against ORX-induced bone loss. (A) Representative μCT sections of tibiae from sham-operated or ORX mice treated with implanted slow-release pellets delivering DHT, PSK3471, or estren-α. (B) The histomorphometric quantifications of μCT data. Values are mean ± SEM; ^†P < 0.001 versus ORX mice.