Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor
J. Clin. Invest. Sara H. Windahl, et al. 116:2500 doi:10.1172/JCI28809 [
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Figure 6Estren-α effects on uterus are mediated by ERs and AR. WT C57BL/6 mice were subjected to sham operation, OVX, or OVX and treatment with estren-α pellets with or without subcutaneous coadministration of the anti-estrogen RU58668 (AE) or the anti-androgen RU58642 (AA). Cotreatment with anti-estrogen decreased the uterotrophic effects of estren by approximately 30%, while cotreatment with the anti-androgen nearly abolished the uterotrophic effects of estren-α.
†P < 0.001 versus untreated OVX mice.
