Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor
J. Clin. Invest. Sara H. Windahl, et al. 116:2500 doi:10.1172/JCI28809 [Go to this article.]

Figure 5
Estren-α, but not PSK3471, stimulates breast cancer cell proliferation. (A) Estren-α significantly enhanced cellular proliferation in MCF-7 cells. Indeed, at 10 nM, estren-α and E₂ displayed the same efficacy. PSK3471, in contrast, did not display any agonist activity on MCF-7 proliferation. (B) The experiment was performed as in A, but the ability of each compound to antagonize E₂-induced cell proliferation was tested by cotreating the cells with E₂ (0.1 nM) and increasing doses of compounds, as indicated. PSK3471, but not estren-α, antagonized E₂-induced proliferation of MCF-7 cells. E₂, filled diamonds; estren-α, filled triangles; PSK3471, filled squares.