Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor
J. Clin. Invest. Sara H. Windahl, et al. 116:2500 doi:10.1172/JCI28809 [
Go to this article.]
Figure 2Estren-α prevents bone loss in OVX female mice. (
A) Representative μCT sections of tibiae from sham-operated or OVX mice treated with implanted slow-release pellets delivering E
2, PSK3471, or estren-α. (
B) Quantification of μCT analysis. Values are mean ± SEM.
†P < 0.001 versus OVX mice;
#P < 0.01 versus sham-operated mice;
##P < 0.01 versus E
2-treated mice. BV/TV, bone volume/tissue volume.
