JCI - Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor

Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor

Sara H. Windahl, René Galien, Riccardo Chiusaroli, Philippe Clément-Lacroix, Frederic Morvan, Liên Lepescheux, François Nique, William C. Horne, Michèle Resche-Rigon, Roland Baron

Published in Volume 116, Issue 9

J Clin Invest. 2006; 116(9):2500–2509 doi:10.1172/JCI28809

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Figure 10

Estren-α increases the weight of seminal vesicles in ORX WT and ERα^–/– male mice.

Male WT and ERα^–/– mice were subjected to sham operation or ORX and treatment with DHT, estren-α, PSK3471, and/or the anti-androgen RU58642 as described in Methods. The seminal vesicles were weighed directly after the sacrifice. (A) Representative seminal vesicles from untreated and treated WT mice. (B) Quantification of the seminal vesicle wet weight in WT mice. (C) Quantification of the seminal vesicle wet weight in ERα^–/– mice. ORX significantly reduced the seminal vesicle weight in both wild-type and ERα^–/– mice. Both estren-α and DHT induced seminal vesicle hypertrophy. These hypertrophic effects were abolished by coadministration of the anti-androgen RU58642 in ERα^–/– mice. ^†P < 0.001 versus matched ORX controls.