Proteasome-mediated degradation of IκBα and processing of p105 in Crohn disease and ulcerative colitis
J. Clin. Invest. Alexander Visekruna, et al. 116:3195 doi:10.1172/JCI28804 [
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Figure 9Double immunofluorescence of proteasomal immunosubunit β2i and NF-κB subunit p65 in the terminal ileum and colon of IBD patients and controls. Magnification, ×1,000. Increased expression of NF-κB subunit p65 colocalizes with enhanced expression of the β2i subunit in intestinal epithelial cells and cells of the lamina propria (green fluorescence, β
2i; red fluorescence, p65). NF-κB was stained with a primary antibody that exclusively recognizes activated p65. Data represent 1 of 8–10 patients per group.
