Proteasome-mediated degradation of IκBα and processing of p105 in Crohn disease and ulcerative colitis
J. Clin. Invest. Alexander Visekruna, et al. 116:3195 doi:10.1172/JCI28804 [Go to this article.]

Figure 10
Schematic overview of enhanced immunoproteasome-mediated NF-κB activation and consequent exacerbation of inflammation in CD patients. Unknown initial inflammatory events induce expression of c-Rel in the intestinal mucosa and a strong Th1 cell response via IL-12. High amounts of IFN-γ trigger generation of immunoproteasomes, which enhances NF-κB activation, thus perpetuating the inflammatory process.