Proteasome-mediated degradation of IκBα and processing of p105 in Crohn disease and ulcerative colitis
J. Clin. Invest. Alexander Visekruna, et al. 116:3195 doi:10.1172/JCI28804 [
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Figure 1Subunit composition of proteasomes isolated from the colon of control patients and patients with IBD. Purified 20S proteasomes from the colonic mucosa were separated by 2-DE, and spots were identified by MALDI-MS. (
A) 20S proteasome subunit pattern of control patients (
n = 6); lines indicate different isoforms of individual subunits. (
B and
C) Subunit composition of 20S proteasomes derived from noninflamed and inflamed mucosa of the colon from UC patients (UC, noninflamed tissue,
n = 5; UC, inflamed tissue,
n = 5) and CD patients (CD, noninflamed tissue,
n = 5; CD, inflamed tissue,
n = 5). Circles indicate increased expression of immunosubunits in inflamed mucosa of CD. Shown are representative 2-DE gels of 5 independent experiments.
