CD40Ig treatment results in allograft acceptance mediated by CD8+CD45RClow T cells, IFN-γ, and indoleamine 2,3-dioxygenase
J. Clin. Invest. Carole Guillonneau, et al. 117:1096 doi:10.1172/JCI28801 [
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Figure 7IDO gene transfer into the graft but not at a distant site results in long-term allograft survival. AdIDO or Addl324 (2 × 10
10 IP) were injected into the cardiac grafts or intramuscularly into the hind limb the day of transplantation. Rejection was defined when beating of the transplanted heart could no longer be detected.
P < 0.001, AdIDO graft versus Addl324 and AdIDO i.m.