CD40Ig treatment results in allograft acceptance mediated by CD8⁺CD45RC^low T cells, IFN-γ, and indoleamine 2,3-dioxygenase
J. Clin. Invest. Carole Guillonneau, et al. 117:1096 doi:10.1172/JCI28801 [Go to this article.]

Figure 7
IDO gene transfer into the graft but not at a distant site results in long-term allograft survival. AdIDO or Addl324 (2 × 10¹⁰ IP) were injected into the cardiac grafts or intramuscularly into the hind limb the day of transplantation. Rejection was defined when beating of the transplanted heart could no longer be detected. P < 0.001, AdIDO graft versus Addl324 and AdIDO i.m.