Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model
J. Clin. Invest. Zhigang Yu, et al. 116:2663 doi:10.1172/JCI28773 [
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Figure 3Early death in AR113Q males is androgen dependent. (
A) Survival curve of littermate N2 WT (red line,
n = 19), AR113Q (blue line,
n = 22), and castrated AR113Q males (green line,
n = 9). Four of the castrated AR113Q males were euthanized at 18 months (indicated by arrow), and the remaining 5 were implanted with testosterone pellets and monitored for survival. (
B) Survival curve of N5 AR113Q males from the original line (black line,
n = 14) and N2 AR113Q males from an independently generated second line (blue line,
n = 14). (
C) Testes of WT, AR48Q, and AR113Q males at 24 months. Magnification, ×400.
