A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN–based vaginal microbicide
J. Clin. Invest. 116:8 doi:10.1172/JCI28681 [Go to this article.]

Figure 8
IFN-γ responsiveness is not required for CpG ODN–mediated protection against genital HSV-2 challenge.

(A) Survival rates, (B) genital mean pathology scores, and (C) virus titers in vaginal washes of WT (129 background) and IFNγR^–/– (129 background) mice were monitored following CpG ODN ivag inoculation and HSV-2 challenge (10⁴ PFU). Values represent mean ± SEM (n = 5/group). Data are representative of 3 independent experiments.