TNF-α downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
J. Clin. Invest. Alessandra Valerio, et al. 116:2791 doi:10.1172/JCI28570 [
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Figure 5TNF-α signaling deficiency partly restores mitochondrial biogenesis in diet-induced obesity. (
A) eNOS mRNA analyzed by quantitative RT-PCR in WAT of standard chow–fed mice (control), DIO mice, or DIO p55
–/– mice. (
B) Oxygen consumption and (
C) ATP levels in WAT of DIO and DIO p55
–/– mice were compared with those of standard chow–fed mice. Relative values are mean ± SEM (
n = 3 per group) when control measurements were assigned a value of 1.0. ***
P < 0.01, *
P < 0.05 versus standard chow;
†P < 0.05 versus DIO.
