Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice
J. Clin. Invest. Manyu Li, et al. 116:2653 doi:10.1172/JCI28462 [Go to this article.]

Figure 2
Reduced litter size correlates with maternal AM^+/– genotype. Reciprocal heterozygote × wild-type matings were established, and the number of viable offspring at postnatal day 21 and the average number of embryos at gestational day 14.5 were determined. The gray bars represent wild-type males crossed with AM^+/– females and the white bars represent wild-type females crossed with AM^+/– males. The actual average number for each cross is recorded at the top of each bar, while the number at the bottom of the bar represents the number of litters examined for each cross. *P < 0.01, ^‡P < 0.05 compared with the reciprocal cross; ^†P < 0.01 compared with wild-type crosses (Figure 1).