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Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor
Ole E. Sørensen, Dharma R. Thapa, K. Markus Roupé, Erika V. Valore, Ulf Sjöbring, Alice A. Roberts, Artur Schmidtchen, Tomas Ganz
Published in Volume 116, Issue 7
J Clin Invest. 2006; 116(7):1878–1885 doi:10.1172/JCI28422
This article Copyright © 2006, The American Society for Clinical Investigation
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Figure 9
Antibacterial activity of extract from organotypic epidermal cultures.

CFU assays using E. coli (A) and S. aureus (B) as targets were performed with extract from epidermal cultures and are displayed here as bacterial survival compared with control samples incubated with buffer alone. As expected, there was no difference in the killing of E. coli with nonstimulated epidermal cultures and TGF-α–stimulated epidermal cultures (P = 0.4, n = 3). In contrast, there was a significant difference in the killing of S. aureus between nonstimulated epidermal cultures and TGF-α–stimulated epidermal cultures (P < 0.041, n = 5). Nonstimulated epidermal cultures did not cause significant killing of S. aureus compared with buffer alone (P = 0.77, n = 5). Mean and standard deviation are shown.

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