PSGL-1–mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells
J. Clin. Invest. Philippe Foubert, et al. 117:1527 doi:10.1172/JCI28338 [
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Figure 4Ephrin-B2–Fc increases EPC proangiogenic potential in hind limb ischemia. (
A) Representative photomicrographs and quantitative analysis of microangiography. (
B) H&E staining and capillary density. CD31-positive capillaries appear in green. Scale bar: 100 μm. (
C) Foot perfusion in mice injected with PBS, nonstimulated EPCs (EPCs), and stimulated EPCs (EPCs + ephrin-B2–Fc, EPC + EphB4-Fc, or EPC + CD6-Fc). Values are expressed as means ± SEM;
n = 10 per group. **
P < 0.01, ***
P < 0.001 versus PBS-injected mice;
##P < 0.01,
###P < 0.001 versus nonstimulated EPC-injected mice. NI, nonischemic; Isch, ischemic.
