PSGL-1–mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells
J. Clin. Invest. Philippe Foubert, et al. 117:1527 doi:10.1172/JCI28338 [Go to this article.]

Figure 10
Schematic model showing how EphB4 activation increases adhesion potential of EPCs. E selectin and P selectin were overexpressed by the ischemic endothelium. EphB4 activation enhances PSGL-1 expression at the surface of EPCs. This allows attachment of the circulating ephrin-B2–Fc–stimulated EPCs via interaction between PSGL-1 and E selectin and P selectin. The attached cells can then migrate to the ischemic tissue where they can integrate into the nascent vessels and/or participate in a paracrine fashion in the neoangiogenic process.