Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells
J. Clin. Invest. Jeffrey J. Ross, et al. 116:3139 doi:10.1172/JCI28184 [
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Figure 2Induction of SMC-specific transcript expression in SD-MAPCs. SD-MAPCs cultured in serum-free conditions with TGF-β1, PDGF-BB, TGF-β1 plus PDGF-BB, or without cytokine (Control). Expression is reported as percent expression compared with RAOSMCs on days 0, 2, 4, and 6 for α-SMA (
A), SM22α (
B), SM-MHC (
C), calponin-1 (
D), or myocardin (
E). Expression on day 6 of all genes in the presence of TGF-β1 was significantly greater than in undifferentiated SD-MAPCs (day 0) (
P < 0.01;
n = 3–6).
