Absence of bacterially induced RELMβ reduces injury in the dextran sodium sulfate model of colitis
J. Clin. Invest. Laila D. McVay, et al. 116:2914 doi:10.1172/JCI28121 [
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Figure 5Short-term DSS treatment inhibits colonic crypt cell proliferation and reduces barrier function in RELMβ
–/– mice in the absence of gross inflammation.
(
A) Ki-67 staining of a Swiss-rolled colon isolated from a RELMβ
–/– mouse after treatment with 4% DSS for 2 days (magnification, ×100). (
B) Assessment of epithelial barrier function through the measurement of transepithelial resistance (TER) in wild-type and RELMβ
–/– mice with and without 4% DSS for 2 days. *
P ≤ 0.01.
