Absence of bacterially induced RELMβ reduces injury in the dextran sodium sulfate model of colitis
J. Clin. Invest. Laila D. McVay, et al. 116:2914 doi:10.1172/JCI28121 [Go to this article.]

Figure 2
Clinical evidence that RELMβ exacerbates DSS-induced colitis. (A) Daily percent weight loss of wild-type and RELMβ^–/– mice treated with 4% DSS (n = 8 per group; mean ± SEM; *P < 0.01). (B) Mean time (days) to onset of intestinal bleeding (hemoccult positivity) and loose stools in wild-type and RELMβ^–/– mice treated with 4% DSS (n = 8 per group; mean ± SEM; ^#P < 0.05). (C) Percent survival of wild-type and RELMβ^–/– mice treated with 4% DSS for 7 days (n = 8 per group). (D) Percentage of the colonic mucosa ulcerated in DSS-induced colitis in wild-type and RELMβ^–/– mice treated with 4% DSS for 7 days (^†P < 0.05). (E) Quantification of TNF-α mRNA expression in the colon of wild-type and RELMβ^–/– mice treated with 4% DSS for 7 days assessed by Northern blot normalized to 18S RNA (^†P < 0.05). (F) Percent survival of RELMβ^–/– mice treated with 4% DSS that received enemas twice daily with either vehicle (PBS) or recombinant murine RELMβ (2 μg/ml) (n = 8 per group).