Absence of bacterially induced RELMβ reduces injury in the dextran sodium sulfate model of colitis
J. Clin. Invest. Laila D. McVay, et al. 116:2914 doi:10.1172/JCI28121 [
Go to this article.]

Figure 2Clinical evidence that RELMβ exacerbates DSS-induced colitis. (
A) Daily percent weight loss of wild-type and RELMβ
–/– mice treated with 4% DSS (
n = 8 per group; mean ± SEM; *
P < 0.01). (
B) Mean time (days) to onset of intestinal bleeding (hemoccult positivity) and loose stools in wild-type and RELMβ
–/– mice treated with 4% DSS (
n = 8 per group; mean ± SEM;
#P < 0.05). (
C) Percent survival of wild-type and RELMβ
–/– mice treated with 4% DSS for 7 days (
n = 8 per group). (
D) Percentage of the colonic mucosa ulcerated in DSS-induced colitis in wild-type and RELMβ
–/– mice treated with 4% DSS for 7 days (
†P < 0.05). (
E) Quantification of TNF-α mRNA expression in the colon of wild-type and RELMβ
–/– mice treated with 4% DSS for 7 days assessed by Northern blot normalized to 18S RNA (
†P < 0.05). (
F) Percent survival of RELMβ
–/– mice treated with 4% DSS that received enemas twice daily with either vehicle (PBS) or recombinant murine RELMβ (2 μg/ml) (
n = 8 per group).